PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
So fun! Looks just like I expected. I like that I could edit the mug to say what I want.
got one for Cole M.'s mother, she loved it! Best mediocrely- timed sex ever!!!
The mug is beautiful and I love it! Thank you for having a handle large enough for a man to hold onto! ♥️
Mug printed nicely. Great gift idea.
Really great! Your custom mugs are amazing and hilarious
lit af my name is Frey and the def isnt true but its so great
Cole M. got me one for my birthday, fastest sex ever
Cole M. got this for me. best sex of my life.
Got it for Cole M. girlfriend. Slowest sex of my life.
Fucking awesome. Bought this while drunk and don't regret it.
Cole M. gifted one for me on my birthday. I will never forget that day. 10/10
I didn’t get one yet but if I did it would also be for Cole M.’s girlfriend, we would have amazing sex
Was a gift and arrived on time. Just as advertised. Lots of fun.
The price is a little bit expensive, but the gift arrived as ordered. Thanks!
The price was a little expensive, but the gift arrived as ordered. Thanks!
Great mug got one for my highschool crush
I was very pleased with the mug and I was thrilled that I could purchase a customized item that perfectly suited the person I was gifting. The only issue I had was that it didn't have the quote from the tv show the word came from as that was pictured on the mug prior to purchase.
Came out just as described! Had the full definition. Very pleased!
Perfect gift As a joke I gave one to my mate but I costumised it. It said tom drunk 24/7 ugly and got lovely hair. The lovely hair part was a joke coz he don’t have any. It was his favourite gift he got for his birthday and he drinks his beer out of it 😂
Great mug…. Got one for Cole M.’s girlfriend.
Review Details
Pro Customization
Create unique products with your own words and definitions
Live Preview
Personalize Your Design
Debug: Product Metadata
| Key | Value (click to copy) |
|---|---|
Copied! |
Return Policy
Made Just For You
Each product is custom-printed with your unique text, making it truly one-of-a-kind.
Defect-Free Guarantee
If your product arrives with printing defects, damage, or quality issues, we'll send you a free replacement.
Custom Orders
Due to the personalized nature of your order, we don't accept returns for change of mind or sizing issues.
Questions about your order? Contact our support team for assistance.