PKA Mug
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Customer Reviews
love this mug! Goes perfect with the Morbius meal.
Had no idea my name had a definition!!
Bought for an inside joke. Perfect.
i love the schizophrenia mug its amazing
This cute mug reminded me of a quote from an obscure biography I found quite by accident in a tiny hole-in-the-wall 2nd hand shop in Portland, ME in 1987: 'The Life and Times of Lazarus of Bethany'. Quote: " We are all walking wounded held together by the scars of our forbearance and the charity of our sisters and brothers." Truer words have never been said.
Love it . Its me down to a T
unlike most mug customization, you can say whatever the fuck you want. Bravo!
i liked that the mug had my name on it and a funny definition, i will definitely buy some for my friends(with their names of course).
I bought it as sort of a gag gift for my son and his new girlfriend and they loved it
I haven't even bought it, it smells nice
nice quality, vivid image
What's funny is the saying that everyone searched for is the one that popped up on the cup. So all the weird gross sayings that people are commenting on are completely out of context to everyone seeing their comment.
I would buy a morbillion of these mugs.
Coffee is good with a banana (minus the Shimflins!)
It was a good gift
AMAZING MUG. Love a good tutti cup in the morning
Great product The mug is of very good quality. Highly recommended!
Guys do i buy a sex mug?
its beautiful. I use this mug every morbing to watch my favorite movie morbius!
EVERY mug I have ordered online through Urban Dictionary has exceeded my expectations! Each (5) is of a very high quality: Clear/Clean printing (ink, color, sharpness, clarity), and Outstanding craftsmanship ("feels" good to hold, and you can tell it "ain't made cheap"). Your company should be proud, indeed.