PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Cute, good quality, *****!
Exactly as expected!
My order was delivered very quickly and was high quality. Glad to add it to my mug shelf.
God is still alive. The existence of this mug shows there is still faith that god is dead and is listening to us. God Bless,
Gay Label Adore this. Ordered for my husband, with the second definition on the back, about the gay filmmaker. Makes a nice discussion starter.
Top notch shipping and exactly what I hoped!!
Best mug i have ever purchased! Subscribe
I love it, but of course the definition Ichose for “Unicorn” is too long and gets cut off after “someone is remarkably attractive.” Is there any way to purchase a second mug that has the rest of the quote on it? They’d make a great set as a present. Please let me know. David Tillinghast dtilling480@gmail.com
"Turtle on my name". A tribute to the 50 odd years of misheard lyrics.
My friend couldn’t stop laughing when I gave it to him!
I got mugged A man mugged me and then said I had da big gaye
I love the costume coffee mug. What can you say that's bad about it. It's your choice after all. It's the best mug and I love it😍😍😍😍❤️❤️❤️❤️
these mugs are amazing. I can't
My Power Bottom Queen loves her eggplant colored mug and I let her celebrate her title whenever she so chooses
I use black hobby paint & small brush to add recipient’s name to back of mug (which I requested be left blank - thank you!). This is a terrific gift for hard-to-buy-for slightly warped friends! BG
good mug but why does it sometimes say creepy things to me kinda sus ngl
up ya bum
Fast shipment Better than expected!
Customer service was very responsive and helpful
Wowzers
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