PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Tee
used it as a cum rag
Great fit and soft material. Gave as gift. Big hit!
Great conversation piece! Plus I can never find anything with my name on it. This was a great find! Will definitely order more!!!!
Got exactly what I wanted.
Exactly what I expected, thanks!
I don't visit Urban Dictionary alit so I only recently saw they offered merch. I immediately started looking up words for potential Christmas gifts. Found the ideal gift for my brother & ordered a shirt. It arrived very quickly and I love it. It's exactly as pictured on the site and being able to customize it with his name makes it perfect. I only hope he loves it as much as I do. Will definitely keep Urban Dictionary in mind when I need to find a great gift.
i love my shirt i made it say sapnap cause yassssssssss
Best This is the best shirt I have ever gotten I love it and I definitly recomend it to any friend named Hailie
So cool to quickly be able to turn a trending phrase into wearable art!
it was really good i put dad with the def of tfu and lol
*clap* *clap* MEME REVIEW. this is so amazing, alexa play despacito 9001
Love this shirt. Got it for my brother for Christmas and I can’t wait for his reaction! Ordered size L and it seems maybe a little big? Thank you!
thankyou for all your kind reviews. For everyone complaining about the spelling we was high on the bezamine while writing it so fuck youuuuuu
I love it
I really love it it's me through and through. Thank you. And when I want another shirt made I will be going through you guys.
ThIs is perfect
Great quality and fast shipping and I just dropped my mug.
This T-shirt is a high quality product. It fits perfectly and is very comfortable as well. I'm totally satisfied with the product and recommend it to everyone. Not to sound like a commercial or anything, but I really am impressed! Check it out for yourself. If you're thinking about buying something, go ahead. I'm sure I'll be buying more for a few friends soon. Thanks guys! I love this shirt! For real.
My niece laughed and loves her custom shirt.
Not only was the product exactly what I expected, I was well informed on the shipping process in a seamless and timely manner!
Review Details
Pro Customization
Create unique products with your own words and definitions
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Size Guide
Measurements may vary by up to 2" (5 cm). Pro tip: Measure one of your t-shirts at home and compare!
A - Length
Measure from the top of the collar to the bottom hem
B - Width
Measure across the chest from armpit to armpit
Size Chart
| Size | Length | Width |
|---|---|---|
| XS | 27" | 16½" |
| S | 28" | 18" |
| M | 29" | 20" |
| L | 30" | 22" |
| XL | 31" | 24" |
| 2XL | 32" | 26" |
| 3XL | 33" | 28" |
| Size | Length | Width |
|---|---|---|
| XS | 69 cm | 42 cm |
| S | 71 cm | 46 cm |
| M | 74 cm | 51 cm |
| L | 76 cm | 56 cm |
| XL | 79 cm | 61 cm |
| 2XL | 81 cm | 66 cm |
| 3XL | 84 cm | 71 cm |