PKA Tee
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Tee
Customer Reviews
This shirt feels great, perfect fit too.
Great looking t-shirt. Good quality. Printing looks good.
Cool I didn’t order anything I just have a lot of free time and not a lot of hobbies
Fun and soft.
Good stuff! Although, I do have a sneaking suspicion that this is cursed. You see, whenever i dawn this top-teir, soft, stylish shirt - I proceed to pass out within 46 seconds. The mere act of making contact with the material insues the process of this countdown starting. If I do not quit contact, i will lose conciousness the exact moment the countown hits 0. And when I regain clarity, I find myself in a bathtub - never mine, but a bathtub nevertheless. In the bathtub, there is always various colours of hairdye. I then have to go back home, shirt stained with dye. Very fashionable though! 10/10
Smooth transaction and nice product, shipping was quick!
good very good worth money!
5 out of 5 I love when people start reading the definition. It's halourious
10/10 yes much good 10/10 would buy again
Fit is true to size, good quality material. Graphics applied well (not off-center or angled as with some products). Quick shipment.
gooderesting the gooderesting thing ever made
Got it for a friend! He loved it
Size was accurate, and printed text was as displayed online. Doesn't hurt that the material is pretty soft either.
mine says "ass" on it lol
Good Decent, comfortable by all means
My wife bought this for me, my only thing about the shirt, is the big Vernon on the front. I think I would prefer it situated and smaller type as if overva pocket. Other than that I love it. Seems to be of good quality and easy wearability, but I have only tried it on, so am uncertain. Thank you for making my day
shirt made me cum
Dick Aww man I love this shirt for eating
people shat on my shirt that said shart and im mad they took a shit on it instead of a shart
Necero's shirt i can use this in almost every phrase. This shirt allows me to do some great stuff with my kids and grandkids! i'd love for anyone who says same to get this shirt!