PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Best Mug ever. I love having the definition for my favorite word on a stylish mug. -ShinobiScout
It was hilarious and I loved it
bloody fantastic. yes you found a real review that isn't from a bot!
So funny and fun to share. Great gift
I have a persona/troll character on Roblox named: HaunCoolGamer, I bought this bc the actual definition of Haun totally fits Haun's brand.😎 10/10: Very epic.
sicko mode mug bought this, great mug. would recommend to friends
Good quality, not cheesy.
It’s an awesome mug
it's great get it with the definition of your b and make it cuteee
Great as punctuation to an inside joke. Very expensive for a coffee cup.
Excellent communication. Prompt service. Quality product.
my friend loves funky monkey mug
Great idea to be able to offer this quality mug. I wish it would have come with the full text including examples listed on Urban Dictionary but I do love the mug. Just bought my 2nd one. Packaging is duarable and perfect for rough transit.
¡Soy profesora de español y lo voy a usar en mi clase en la universidad!
I wish the text on the back wasn’t so small—if I had to order it over again I would’ve inquired as to whether the words could be enlarged so it filled up more of the “white space” on the back
You guys are fantastic! Will continue to do business with you. Thank you so very much.
Now I have a UD mug! Good quality, nice printing, great definition!
Your company did an excellent job with our order. The beautiful mug with our son's word and definitions arrived in perfect shape, thanks to your outstanding box design! I have never seen a box so cleverly made. I cannot bring myself to recycle it;). The mug will be enjoyed for years to come. Many Thanks, Deborah Crosley Holland and Michael Holland
Got this mug for my daughter and she was taken a back. I explained to her why it was funny, but she didn't seem to understand. Its been a few days since my daughter has talked to me. I'm positive she loves it! I'm hoping to hear from her soon :)
Arrived before my daughter’s birthday, which was good. Not chipped or cracked, so that was good, too. Ichabod Crane looked good on the ferra color.
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