PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Item came at appropriate time in good condition.
epic
Got exactly what I wanted. Very happy with my mug.
It came faster than I thought it would and it looks great!
i am literally shitting literal bricks please help my asshole is on fire
Looked great, came earlier than expected, and in perfect condition!
It came faster than I thought it would and it looks great!
Ur momgay Very cool it is. mmmmmh very much I like.
Every Aspect of my Order (as First-Time customer) was actually very good, nice. .I ordered a white drinking mug with a Red background with text. would recommend this Site again.
so cool! u can make sarcastic stuff too. i put: sarcasm: being an absolute asshole
Like the mug for my daughter, but didn’t notice that I had color choices when checking out. The yellow was pre-set so I got that color. Would much rather have selected a different color.
Cute, well-made mug! Exactly like the photo. I can't wait to give this as a gift this Christmas!
The description of a person by their names is the realest I’ve ever come across
Mug looks great and everything is spelled correctly.
I love my mug! 💘
the photo is all you need to know.
It’s pretty damn cool
It was a really good hoe mug!!!!!
Exactly what I was hoping for! Great product
My coworkers see all the cups I order from you, and this one is already one of their faves
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