PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Having my first cup of coffee in the new cup. Good idea to add new terms through individual contributions.
10/10 Looks exactly like the preview. Shipping was fast.
This is for my granddaughter whom I used to call cutie patootie until she found out another meaning for patootie. Then she didn’t like the name so much! This will be a perfect gift for her! She is 16.
Love the cups :) It reminds us of our sweet momma. I thought everyone knew the word "mommicked" but evidently it is an Eastern North Carolina thing...My sisters and I all married Northerner/ Yankees and they had never heard of the word. Thank you for a tender memory.
Cup came in one piece and looks as nice as it does in the picture! Only note is just be mindful of any typos in the description of the definition, they will show up on the cup too! Other than that, no complaints!
This reminds me of the amazing teams i worked in!
great experience, with fast delivery. Thank you!
my grandma loved it!
My grandma is HOOKED
Based mug
This mug makes me happy :) reminds me of so many funny high school memories!
The mug came quickly and we love it!
These mugs are always good. I usually choose the neon green!
The mug is pretty and the writing on it is clear. It is of good quality and it makes me smile.
Well madder nice print. 8 0z cup. I'd prefer a mug but will be ordering 3 more. Just my cuppa tea (or coffee). Americans always make fun of some of the things I say. Recently my brother and I were talking about the Trawna Maple Leafs. I decided to look it up and sure enough there is was Trawna the city I grew up in. Now who has the last laugh.
I ordered pink but got purple, and the text wasn't very clean, but overall, it is a mug.
It was a gift for my sister, who wrote it. She loved it and so did I!
pushin 🅿️ w this mug😩
Got a ligma mug it's my favorite mug now
Arrived quickly, nicely packaged, exactly as expected, a good quality mug. Thank you!
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