PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Mug
Arrived on time. Great packaging. Communication with vendor was top-notch. High quality item.
I love it! Thanks! So
Great present for a retiring colleague with custom saying she's known for!
Loved this mug! So unique and you can edit the text to add something unique.
I gave it to my friend who took money from me and never returned.
I love the fact that I was able to customize my name since I've never been able to find anything with my name. The only downside is it's smaller than I thought it would be (I guess I didn't pay much attention to that), wish it was bigger, only about 10 oz total.
It's simply awesome; and plus, the word means a lot.
Really fast and looks great! Took a chance on Christmas gift and it was a success!
Awesome mug feels really nice good weight and color although I think the shade could be a little brighter when it comes to the highlighter yellow, I am still pleased with the outcome and the fact that a whole passage was so neatly printed onto the product, very pleased with the packaging too! That made it so easy to wrap just in time for Christmas. Who knew!!
okay so the mug was mid but when you have a genz meme and give it to one of the most serious people you know then it's pretty funny
Nice mug, great feel‼️
Perfect!
Good quality ceramic cup! Worth the novelty price!
Perfect gift for my gf
Looks great! Came quick
Gave it to my nerd brother. He used it consume liquid
Love it
as a fan of non-Z-generation-UD (since 2000 more or less) , especially of old-school definitions ("phat!") (as Nick, the more time passes by, the more I reach my inner age = 75 XD) , I totally appreciated the delivery in time for Christmas! (whispering) Perhaps printing quality in the Spain printing company is not as good as in the US, but - hey! - I got it before Christmas as a gift for my thank-God-non-Gen-Z-sister! ;) hugs from the eighties, and from Italy, and thanks! Mario
This is SO cool. Morning coffee will always memorialize my new addition to the English lexicon.
Too inappropriate
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