PKA
Protein Kinase A G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The Urban Dictionary Tee
hehe mine said skibidi
Feels great love the shitt
Great shirt. Great service. Shopify doesn’t track the shipment accurately though. However, when I reached out to Urban Dictionary customer service, they were able to help me.
Wore it to school.
Love this shirt so much
I love this t-shirt that says morbussy. It allows me to show off both my love for Morbius and the fact that I get no Morbussy.
This shirt feels great, perfect fit too.
Great looking t-shirt. Good quality. Printing looks good.
Cool I didn’t order anything I just have a lot of free time and not a lot of hobbies
Fun and soft.
Good stuff! Although, I do have a sneaking suspicion that this is cursed. You see, whenever i dawn this top-teir, soft, stylish shirt - I proceed to pass out within 46 seconds. The mere act of making contact with the material insues the process of this countdown starting. If I do not quit contact, i will lose conciousness the exact moment the countown hits 0. And when I regain clarity, I find myself in a bathtub - never mine, but a bathtub nevertheless. In the bathtub, there is always various colours of hairdye. I then have to go back home, shirt stained with dye. Very fashionable though! 10/10
Smooth transaction and nice product, shipping was quick!
good very good worth money!
5 out of 5 I love when people start reading the definition. It's halourious
10/10 yes much good 10/10 would buy again
Fit is true to size, good quality material. Graphics applied well (not off-center or angled as with some products). Quick shipment.
gooderesting the gooderesting thing ever made
Got it for a friend! He loved it
Size was accurate, and printed text was as displayed online. Doesn't hurt that the material is pretty soft either.
mine says "ass" on it lol
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Size Guide
Measurements may vary by up to 2" (5 cm). Pro tip: Measure one of your t-shirts at home and compare!
A - Length
Measure from the top of the collar to the bottom hem
B - Width
Measure across the chest from armpit to armpit
Size Chart
| Size | Length | Width |
|---|---|---|
| XS | 27" | 16½" |
| S | 28" | 18" |
| M | 29" | 20" |
| L | 30" | 22" |
| XL | 31" | 24" |
| 2XL | 32" | 26" |
| 3XL | 33" | 28" |
| Size | Length | Width |
|---|---|---|
| XS | 69 cm | 42 cm |
| S | 71 cm | 46 cm |
| M | 74 cm | 51 cm |
| L | 76 cm | 56 cm |
| XL | 79 cm | 61 cm |
| 2XL | 81 cm | 66 cm |
| 3XL | 84 cm | 71 cm |