eugenics
Eugenics are the practice of isolating negative genes, and preserving positive ones, whether through natural or social selection. Several attempts have been made, throughout history, to do such, with human intervention - all were short-lived, but none succeeded. Such methods toward eugenics are: genocide, bioengineering or genetic manipulation, and selective breeding. Through natural selection, random or adaptive mutations occur. If positive, in theory, the traits should prosper. If negative, or not beneficial, however, they should fade away, if the family possessing these genes doesn't die away before then. With human intervention, this is accelerated - the isolation of carriers of certain DNA can be achieved without blood shed, simply if no other group interbreeds, or if such a group discontinues populating. However, more macabre means can be undertaken to reach this, such as genocide. Still, yet, there are further, and possibly more promising methods, such as genetic manipulation, for carriers of such a trait could be "cured," rather than phased out, or exterminated, altogether. Examples in history, involving humans, include: murder, en mass, of American Indians; the Holocaust (1933 - 1945); the Balkans ethnic cleansing (Bosnia, Kosovo, primarilly); Rwanda; Sudan; etc.
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