Pyrrolizidine Alkaloidosis Mug
Pyrrolizidine alkaloidosis is a disease caused by chronic poisoning from ingesting plants that contain pyrrolizidine alkaloids (PAs), a group of more than 30 phytotoxins produced by various plants as a natural defense mechanism. These toxins are metabolized in the liver into highly reactive pyrroles, which cause cytotoxic effects by cross-linking DNA and other cellular macromolecules, leading to irreversible damage in target tissues, primarily the liver. The condition typically results in hepatic failure and is characterized by a delayed onset of clinical signs, often appearing weeks or months after exposure, even after consumption of the toxic plants has ceased. Pyrrolizidine alkaloidosis is most commonly associated with plants from the genera Senecio, Crotalaria, Heliotropium, Amsinckia, Echium, Cynoglossum, and Trichodesma, which grow in temperate, tropical, or subtropical climates. Animals such as cattle, horses, pigs, and farmed deer are particularly susceptible, with young, growing animals being most vulnerable. The disease can occur through ingestion of fresh plants, hay, silage, or contaminated grain, as some toxic compounds survive drying processes. Clinically, the disease manifests as progressive liver damage, with signs including loss of condition, anorexia, dullness, diarrhea, ascites, jaundice, and hepatic encephalopathy such as head-pressing, aimless wandering, or aggressive behavior.
The Urban Dictionary Mug
Customer Reviews
cure my depression really good i love it. also my dog cant stop doing things to it.
Easy to order and customize. Very tough, solid, and well-made. Nice and hefty in the hand.
I just LOVE this woosan mug! Amazing quality
Looked great and delivered fast.
Great product
What a hoot. On my kitchen counter. Of course. Any publicity, right? Still liberal. Leeza
My friend loves his gift coffee mug!
urban dictionary is my personal lifeline to the divine, thank you for selling me a $35 coffee cup that I gave to friend, bought another and gave that another friend. Likely asking, rather in need of, a six or more discount code, for six or more gifts to friends! Xoxo
just been amazed by the name actualy my real name that is on the birth certificate is BILLIAM ...thanks for using my name on great good things i would just wish to come and visit and if possible work der thank you
My friend was going through a tough time and this mug really cheered her up! It was the perfect gift.
Mug is of excellent quality. So funny! My daughter will love it!
Got it as expected. I love how UrbanDictionary store kept in contact with me as the order progressed. Thanks for a great experience and I look forward to getting more mugs LIKE this.
Loved it!
My 4th cup purchase just love them
He loved the mug!
The cup is very nicely designed
Got as a gift for a friend and he loved it and thought it was really funny. Great quality and very strong feeling build.
Great mug. Super customer service!
Love their products. Have bought numerous mugs. Buy 'em.
If you buy these mugs. You are a giga chad