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A homunculus is a failed attempt to revive a dead person using the art of alchemy in the anime [Full Metal Alchemist]. (This practice is often referred to as human transmutation, and is forbidden.) There is some ambiguity whether or not a homunculus is truly a [reincarnation] of that person. A homunculus is not a human and supposedly has no soul. However, Lust and other homunculi are able to recall events from their past life.

Homunculi are nearly [indestructible] and do not age. In addition, each one has a special, deadly power. For example, Lust can extend her nails to use as a deadly weapon and Sloth can transform from a solid state to that of a liquid. Homunculi become paralyzed when in close proximity to parts of their former bodies. The resulting paralysis or loss of consciousness often aids in one of the few ways to kill a homunculus: sealing via an alchemical array. This causes the homunculus to expel the red stones which fuel them, and results in the body of the homunculus dissolving and/or weakening. Most homunculi are incapable of using alchemy, but there are exceptions.

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