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a.k.a. "losin' your soul" Common iterations include losing my soul, losing his soul, [lost] his soul, [lost] my soul, etc. Phrase meaning: simultaneously vomiting whilst sitting on a [toilet] and relieving your bowels. It may also be reversed, in which the victim is vomiting headfirst into a [toilet] while he loses bowel control. Usually the consequence of heavy drinking, food poisoning, or a combination of the two. There may not be definitive proof that the soul exists, but this is strong evidence that after experiencing this situation, one can now prove a lack thereof.
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