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to feel disgust , [disappointment] or anxiety. When one is fed up with [everything] in life. This could pertain to the weather, bfs, gfs, friends, school, work ETC. To feels anxious, or perhaps bored with life, one should utter this phrase as a method of stress relief. To throw up literally means to rid ones self of toxins in the body, in this [metaphorical] case, life as a whole!
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