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Garbage drug (dud) that doctors describe for you when they don't like you or when you are [mentally ill] or in rehab. It is not even good medicine for [mentally ill] people as it is uneffective and too sedative for day use.

Seroquel (non-XR) is short-acting (half-life 7h) meaning that receptors open and close [all the time] and this can cause damaging serotonin peaks in brain. Higher doses (>150mg) reduces bood flow to brain and lower doses increases it but if seroquel IR is taken once daily (as sleep aid) adrenergic receptors open and close all the time causing damaging fluctuations to blood/oxygen supply (to brain) and damage to bood vessels. Quick changes ind dosage are [problematic] because adrenergic system is now oversensitive causing further blood circulation problems to brains and organs (vasoconstriction).

Overall the drug just doesn't work well. All antidepressants used for sleep have usually much longer half-life. Adrenergic drugs must be stoppen gradually.

Use proper alpha blockers+antihistamine or antidepressant instead of seroquel. Extremely low doses (<25mg) can be used as antihistamine but why not use proper antihistamine instead.

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