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a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme [intoxication]. Users were left alone when they "tweak," or are "[tweaking out]" until the initial strong effects of the drug wore off a little and they were more coherent. The term has come to loosely refer to being high on speed, as well as [unfortunately] children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
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