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The "Buffalo Theory" is a comparative theoretical hypothesis which attempts to predict the cumulative effects of drugs/alcohol upon the brain over time.

The theory states that: 
"damage to the brain brought about by excessive consumption, acts as a 'clean-up agent', damaging or destroying weaker brain cells before their sturdier [counterparts], raising the proportion of the brain that these stronger brain cells represent, thereby improving the overall quality of brain output, through a process analogous to [natural selection] in animals."

Earliest records indicate that Giles **** originally published details of the theory to friends on a night out.

The name 'Buffalo Theory', comes from the analogy with [natural selection], [particularly] within the buffalo community. Giles states that just as, "the weaker buffalo of the herd get picked off by predators, leaving the stronger, more intelligent members to procreate, the weaker brain cells are picked off by consumption, leaving those which are better suited to a drink-and-drugs environment."

Skeptics and criticizers of the theory widely believe that Giles announced his theory to justify his own excessive consumption, which he denies frequently by throwing empty wine bottles. It is also not yet known whether excessive consumption does in fact only kill off the weaker cells.

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