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1. Mesembrine is an alkaloid present in Sceletium tortuosum. 2. It has been shown to be an [extremely] potent serotonin reuptake inhibitor, active at dosages as low as 100μg (micrograms). 3. It has also been shown to be a PDE4-inhibitor.3 Mesembrine may [contribute] to the [antidepressant] effects of kanna.
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