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The problem of underdetermination: For any given body of [scientific] evidence, there are always multiple, logically possible theories that can explain it equally well. Data alone cannot force us to choose one theory over another; extra-scientific criteria like [simplicity], elegance, or [compatibility] with other established theories (paradigm loyalty) must be used. The hard problem is that these criteria are aesthetic and pragmatic, not purely empirical. Thus, the move from evidence to theory is never a strict logical deduction, but a creative, sometimes subjective, leap.
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