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When someone is piss pilled, it means that they are generally an angry person who is always pissed off, and will likely be miserable their whole lives due to their constant [irritability]. Dubbed piss pill because of the whole red pill/blue pill whatever pill concept of the matrix, but unlike the other pills, the piss pill makes it's users live a live of "pissful [ignorance]," or live a life where [everything sucks] and they're always pissed off.
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