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Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy.3 While it has been used in a number of HIV-associated conditions, such use is [associated] with increased levels of the [virus].3 It is administered orally. Common side effects include sleepiness, rash, and dizziness.3 Severe side effects include tumor lysis syndrome, [blood clots], and [peripheral] neuropathy.4 Use in pregnancy may harm the fetus, including resulting in malformation of the limbs.3 In males who are taking the medication, contraception is essential if a partner could become pregnant.4 It is an immunomodulatory medication and works by a number of mechanisms, including stimulating T cells and decreasing TNF-α production.3
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