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this is a ruder version of: don't get your knickers in a twist but it literally means - don't get your fanny in a twist it can also refer to ugly vaginas that appear "twisted" , telling a woman that she has a twisted ham can mean that they have a gross or ugly vagina or it can mean that they are unfeminine. Telling a man he has a twisted ham means that he is too feminine and or a male prostitute which would mean that his asshole has stretched out so much that it looks like an ugly vagina.
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