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A pejorative term. The feeling and/or sensation of a mind/body altering drug that when taken and effects become noticeable, [particularly] pharmaceutical drugs, rather than wanton and desired sensations (i.e. Euphoria, Elevated Mood, Pain Abatement, Overall Positive Vibe, etc) upfront and foremost substance feels unnatural, a [disturbing] sensation that is 'complex', heavy, something expected from neuro or blood pressure drugs, something akin to wearing the wrong sized shoes or a jacket on a hot day. A substance that when imbibed relentlessly lets [you know it] is a pharmaceutical. A complaint [associated] with the likes of Lithium, Seroquil, and Promethazine. Can also be used in a non-pharm sense such as in toking schwag with [plentiful] stems & beans versus an OG, Northern Ligjts, or Panama Red. Crawling skin, vertigo, lethegy, slow-mindedness are some additional symptoms. Akin to the experience of having a refined palate for beer, typically choosing Sierra Nevada, Bass, or Red Hook, when you have that unscratchable itch for a cold one and someone serves you a Keystone or Natural Light--sourced from Utah no doubt where beer is a mnadatory 3.2%. You drink it, but not out of disgust or revulsion the body/mind simply does not want it or can enjoy it; you feel a quesy, off-putting, a not-quite-right sensation entirely--it knows. Almost a mild form of poisoning. Can be [associated] when purchasing bunk or forged drugs like Fentanyl or Methadone in a supposed 15 or 30 mg oxycodone.

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