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The point at which you realize that putting all that shit up your nose probably wasn't such a good idea cuz you haven't slept the last 2 nights and you spent a lot of cash but you still want more but you know you shouldn't and your eyes want you to sleep but your body sure as hell ain't ready to, and your brain has been losing the initial sharpness and clarity that Day 1 brings, slowly turning you paranoid, edgy, jittery, unfocused and susceptible to sleep-deprivation-induced chasers and visuals. Precursor to Days 4,5,6,etc. which do NOT get any better, just progressively worse, until the inevitable CRASH.
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