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To destroy, damage, wreck, ruin, or generally f*** something up to the point that it's unusable, or to f*** someone up or pop a cap in their ass. Can also be used to refer to doping a racehorse or an athlete. "What's the betting someone tries to knobble Golden Thunder before tomorrow's big race?" (Racehorse/Doping) "I don't give a rat's ass whether he apologized. I want you to go and knobble Sammy the Squealer. Give him a long wet nap." (Mafia/Gangster/destroying someone)
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