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Basically a phrase meant to piss people off. If you think about it, many words can fit between "U" and "BRO?", with the most common outcome of "UMADBRO?", indeed one of the most annoying phrases in history. Women may be offended by this, most likely due because they are not male, however if you ask something like say "UMADSIS?" it just wouldn´t sound right. Be advised to use "BRO?" instead of "SIS?" to prevent yourself from looking like a total dickhead.
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