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LUEicide, like it is originially called, is a term most used by people that visit the GameFAQs board "Life, the Universe, and Everything", or simply called "LUE". The "Icide" part at the end of the term LUEicide, stands for suicide, which means killing yourself. A LUEicide is killing not yourself, but your GameFAQs account on LUE, which became a very populair way of getting rid of your account if you don't want it anymore.
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