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The full phrase is "the best laid plans o' mice an' men gang aft agley" This was written by an ancient Scots Poet, [Robert Burns], who wrote several poems in a strange language, including "To a mouse". "Gang aft agley" means "often get fucked up" "best laid plans" is an [acknowledgement] that something has just got fucked up for no apparent reason, or because something [inevitable] (government, parents, teenage kid, fate, whatever) has acted against it.
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