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A hand gesture/expression in which an individual makes two back to back sixes with their hands (similar to the "okay" hand gesture, with the thumb and pointer finger touching and the other 3 fingers sticking straight up). There are many uses of the expression/gesture. "Throwin' your sixes up" can be considered similar to the middle finger, but slightly less offensive. It is typically used by and individual to show that they thing something is wicked or sick. Also, it can be used by an individual to show that they don't care about something. The origin "throwin' your sixes up" is associated with the number 666.
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