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This is a more inside way of saying you have to [drop a deuce] ([take a crap]), it works really well in an office setting so that you may let your close, personal co-workers know where you are going without letting everyone else know. This is derived from John Wayne's nickname being "The Duke", and can be shortened by simply saying "I have [to make a phone call]", or added to by saying "man John Wayne has been calling me all day."
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