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tweetesis tweet⋅e⋅sis tweet-uh-sis –noun, plural -ses /-ˌsiz/ Pronunciation -seez 1. something that a person cannot conquer, achieve, etc. on Twitter: The fact that no one follows me proved to be my tweetesis when trying to get my message out. 2. an opponent or rival whom a person cannot best or overcome on Twitter. Especially someone who disagrees pointedly with a tweet. 3. an agent or act of retribution or punishment on Twitter. HISTORY Originally coined February 1, 2009 by @ADMAVEN and @thedirtyblonde on Twitter to describe their interaction when arguing over humor in a Superbowl advertisement.
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