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verb. When something is going really, really well, then all of a sudden the whole situation gets totally fucked. Literal translation/origin: Girl sends Guy a booty call text message at 2am, but when Guy shows up, there's two dudes just chillin on the couch with Girl. As such, the guy got "two-dudesed." Similar to cock block or buzzkill. Can also be used to imply "fucking shit up." "Two Dudes" may also be used as a noun referring to a person who constantly ruins kickass situations.
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