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A form of brain-damage in those who program too much in the write-only computer language Perl. In it's most basic form, a Perl programmer will use Perl to accomplish common tasks for which other more appropriate (and easier) tools already exist. In extreme cases, those suffering from Perl Syndrome will set their login shell to Perl, and replace system executables with their own Perl monstrosities. When confronted with evidence that they have Perl syndrome, one afflicted will become upset, deny that there's anything wrong, and respond "TMTOWTDI" ("There's More Than One Way To Do It" - Perl's motto.)
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