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As defined in South Park, an episode in which the kids decided to post a false missing ad for Kenny on the milk cartons and a couple with Tolsatic Polarity Syndrome (TPS) claim the son is theirs. Symptons include: Speech impetiment of making a frt sound during crying and pronouncing the letter S. Throwing up after consumption of chili and laxatives. Ocassional belching. A habit of telling people you have TPS when it is very obvious every damn second. This disease is so funny it almost made Cartman claim he can no longer laugh since he "saw something so funny he will never see anything again that is so funny".
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