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Mako is part of the lifestream, that is a good source of energy and is used by Shin-Ra corp. This substance, after thousands of years, can harden, changing to materia, which is used as a magic source. It is the complete opposite of Jenova Cells but can give the same effect if injecting or used on a person. Vincent Valentine was fused with mako, according to Dirge of Cerberus. This fact was never mention in the original game.
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