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The controlled production, containment, and utilization of antimatter as an energy source or propellant. When matter and antimatter annihilate, 100% of their mass is converted to energy (E=mc²), making it the most energy-dense reaction known to physics. The monumental challenges are producing enough of it (it's incredibly rare and expensive to make) and storing it (it annihilates on contact with normal matter, requiring electromagnetic "bottles" in a perfect vacuum). If mastered, it would enable interstellar travel and immense power generation.
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