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The difficulty in defining the soul as a distinct, non-physical entity that is the seat of identity and consciousness, and then explaining how this immaterial "thing" interacts with the material brain. How does an ethereal soul without mass or energy cause neurons to fire (the mind-body problem on steroids)? If it doesn't interact, it's irrelevant. If it does, it should be detectable. The soul often ends up defined only by what it is not—not physical, not mortal—leaving its positive qualities mysterious.
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