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Typically used in terms like cisgender or cissexual. Cisgender people are those who remain their gender observed at birth by the doctor, cissexual refers to people who are attracted to those who are their birth gender. Can also be used as an acronym like "Comfortable In Self" which can imply those who are choosing a different gender than at birth (transgender) aren't comfortable with their existing self prior to transitioning which is true given gender dysphoria as a mental illness.
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