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Nicki said this on instagram live about Megan Thee Stallion during their internet beef. This is one of the funny things she probably said during that entire live. I’m pretty sure it’s something that is referred from the Bible about the serpent that tempted Adam and Eve in the garden of Eden. “Loose” as in “serpent get away from me”. Nicki was saying that Megan was a serpent who needs to leave her alone.
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