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1. When someones been on drugs a long time and it's affected them noticeably, like when they do some tweaker like or just dumb addict type shit 2. Someone thats just so detached from reality and dumb that they seem npc like but not quite, like borderline retarded, not like the downs or autism or other special way, but just slow or dumb like empty headed 3. Someone thats just so outta pocket kind of fucken weird, tweaker-y, or perma fried stoned that you dont know wtf to say when they do something
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