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When someone is referred to as "Piss pilled", it means that they're generally bitter, resentful, and often angry/upset at/towards others for no reason, or an irrational reason. They are called "Piss pilled" as a take on the 1999 film The Matrix, in which there is an option for the protagonist to take the red or blue pill, each with a different consequence. In recent years, red and blue pills have garnered more attention and relevance in popular Internet culture, as they have gained deeper meanings, and more pills have been made up. Too long didn't read, taking the Piss pill means that you have chosen to live a life of "pissful ignorance," or a life where you are always pissed off and everything sucks for you.
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