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Anol, also known as para-hydroxypropenylbenzene, is a simple phenol that was derived via demethylation from anethole, an estrogenic constituent of anise and fennel, by Sir Charles Dodds in 1937. It was reported to possess extremely potent estrogenic activity on par with that of steroidal estrogens like estrone. It was found that dimerization of Anol into dianol and hexestrol can rapidly occur and that the latter impurity, hexestrol, was responsible for the highly potent estrogenic effects.
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