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Depakote Valproate (VPA) and its valproic acid, sodium valproate, and valproate semisodium is an anticonvulsant. It can treat seizures and bipolar disorder. It can also help prevent migraine headaches. Depakote can treat depression and anxiety. It lifts your mood and reduces anxiety. Proposed mechanisms include affecting GABA levels, blocking voltage-gated sodium channels, and inhibiting histone deacetylases.
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