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1) In street culture influenced by Chicago gang culture and Drill Music, "we up" is an oblique reference to the score. The score is a record of gang members slain by their rivals. Each death demands reprisal. Literally, then, to be "up" means that your side has killed more of their side than they have of yours; you have a net positive account of bodies. 2) To be "up" also means to be solvent, to have drugs to sell, and to be powerful, on point, in the sense of "on top." This wider usage is probably because the direction "up" usually corresponds with positivity, happiness, and thought in our culture, according to George Lakoff.
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