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Harlequin fetus refers to an extremly rare genetic disorder that affects the formation of skin. Skin is ridged cracked and hardened, forming plates. Since these plates cannot flex deep cracks form allowing infection to penetrate the skin immediatly upon birth. The disorder distorts the facial features and constricts the digits. Harlequin fetuses are either stillborn or die very soon after birth. Mothers with a family history of the disease are screened during the early months of pregnancy, pregnancies affected by it are terminated.
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