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The backlash one experiences after a weekend of partying, [usually] on the [designer drug] ecstasy, the following tuesday after said weekend.

For reasons not clear, most ecstasy users have a 'hold-over' day in the 24 to 36 hour period following comedown (the ate up period), where the 'down' effects of the drug don't become apparent. This 'hold-over' day usually falls on a Monday if [Saturday night] was the day of usage. [The next day], the Terrible Tuesday itself, is usually a day filled with depressive feelings and overall sadness and malaise. Dealing with critical issues is almost impossible and one is almost guaranteed to have mood swings. 
 
Usage of the supplement 5-htp is recommended along with a bottle of Pedialyte immediately after coming down off of the roll in order to dampen, if not completely neutralize, the depressive effects from the E.

True origins are unknown, but most experts in the subject area agree that the term was probably coined during the ecstasy wave of the 90's and the subsequent rise of EDM (Electronic Dance Music) subculture in America.

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