a website mostly made out of NSFW furry artwork, there are some SFW but everyone ignores them It is also home to a lot of cursed artworks
Person 1: yo, check out this WoW porn I found! Person 2: Hell Nah, I'd rather jack off to the shit on e621 than see that shit
By ThunderTheFurry
a place where can find a lot of furry porn and be able to sort by many different categories like if you were looking at rule 34
me: alright guys im going to jack off to furry porn on e621 my friend: wait what the fuck
By zeno the protogen
It's the E number for Monosodium Glutamate (aka MSG). The furry imageboard with the same name most likely named itself E621 to address how 'tasty' their content is. Funnily enough, there's a forum named E926 (the E number for bleach) that exists as an eye-bleach after one views the 'tasty' content of E621.
Person 1: E621 is love, E621 is life Person 2: Ew, miss me with that furry shit
By Obv troll is obvious
E-number for Monosodium Glutamate, a common food additive that has a distinct umami taste. Also refers to a particular website...
Alice: E621 tastes really good! John: What's E621? Alice: You'll soon find out...
By レム
e621 is an image board focused on furry artwork as well as other fetish art.. Do you know what furries are? You should. Much of the content is pornographic in nature, and it contains many hardcore fetishes. Its cleaner counterpart is e926.
"e621 is a cursed website."
By Deutsches Kaiserreich